You can use folder protection to back up your important folders on your PC (your Desktop, Documents, and Pictures folders) with OneDrive, so they're protected and available on other devices
Refer to this Microsoft Article for instructions on how to setup OneDrive folder sync:
Sync-your-documents-pictures-and-desktop-folders-with-onedrive
Note: Syncing the "Desktop" folder should be used with caution since it may sync shortcuts to programs that are not available on all of your devices.
For more information on OneDrive at Princeton - refer to Microsoft Office 365 OneDrive for Business